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Jan. 23rd, 2006

Dear Zool.

Xenical has become an over-the-counter recommendation as a weight-loss treatment.

Apparently the drug serves to "condition" you into eating less fat. It does this by converting some 25% of the fat into "something that your body doesn't like very much". The result, as one doctor put it, is "explosive diarrhea".

He said that the drug was "not too popular" among those patients that he prescribed it to.

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( 1 comment — Leave a comment )
lexinatrix
Jan. 24th, 2006 08:08 am (UTC)
I heard on NPR that up to one third of consumed fat was left undigested, the result being "frequent, loose stool" combined with a "sudden urge" to crap. So, yeah.

It doesn't really condition you to consume less fat. It just inhibits the enzyme that digests fat that you've consumed. It was proven most effective on people who don't have high-fat diets to begin with, and while the most recent study showed more than double the weight loss in those using the drug, that amounted to only 10-12 more lbs lost.

Like you said, most considered the side effects to be intolerable, given the nominal weight loss associated with taking the drug.
( 1 comment — Leave a comment )

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